The Manchester derby is the headline act for Matchday 16 of the Premier League season, as Pep Guardiola's side looks to try halt their recent slump in form by beating rivals United in Ruben Amorim's first taste of the fixture.
Elsewhere, leaders Liverpool entertain Fulham, while there's a tasty-looking West London derby between in-form Chelsea and free-scoring Brentford.
Here is Harry Redknapp giving his predictions for the weekend to BetVictor.
Manchester City 2-1 Manchester United
What a big game for both sides! Another Manchester City game during the week, another defeat, it’s just unbelievable. Losing to Juventus can happen, but City didn’t really look like scoring, Erling Haaland was so isolated.
As for Manchester United, it’s hard to really judge Ruben Amorim right now.
At least half this squad might not be here this time next season and he’s clearly trying to figure out what he’s got it, who he can rely on.
I like how he’s trying to implement a formation and a style of play, but he does need to get wins to go alongside that.
Despite City’s form, I just think they’ll have too much here, particularly at home.
One to watch - I’m a huge fan of Phil Foden but I’ve got to be honest, he’s been a disappointment this season. It’s about time for him to show his best form.
Chelsea 3-1 Brentford
I think Chelsea look superb at times. Some of the football in that win over Tottenham was just brilliant. They’ve got their issues at the back but going forward, I just don’t see much better. This could be an exciting season for the fans.
Brentford are having an amazing time; Thomas Frank just doesn’t get enough credit. They’ve struggled a little bit on the road though, most of their points have come from winning these thrillers at home!
I’ve got to pick Chelsea. Brentford might get a goal because I don’t fully trust this Chelsea defence but there’s too much attacking quality here.
One to watch - Cole Palmer was just a complete joy to watch last week. I know people will say it was only two penalties but it’s not a foregone conclusion to score them, particularly in such a classy way! What a player.
Liverpool 2-0 Fulham
Liverpool didn’t play at the weekend but with Arsenal and City dropping more points, it worked out in the end. Slot wasn’t all that happy with the Champions League performance the other night but it was yet another win and they’ll be confident here.
What a good side Fulham are. They always give every side a game and I can really see them pushing for the top eight this season if they can keep everyone fit.
I just think Liverpool are in such a good place right now and I can’t see them slipping up here.
One to watch - I always say Mohamed Salah but I’m going to go with Cody Gakpo here, I think he goes under the radar and is a top player.
Arsenal 2-0 Everton
I don’t know what to make of Arsenal at the minute, they’ve been inconsistent. Look, Fulham are a decent side, particularly at home, but Arsenal can’t be dropping points like that. People have said it for a while, but I think the lack of a real top-quality striker has hurt this side.
Everton obviously didn’t play at the weekend, so they’ll arrive here fresh and quite up for it. Their form on the road has been poor though, particularly against the top sides.
I just can’t see Everton having much of the ball or really laying a glove on Arsenal, 2-0.
One to watch - Kai Havertz needs to start scoring more. He started the season in good form, but he’s been quiet lately.
Southampton 1-2 Tottenham
Southampton have played well enough in recent weeks, but they just don’t get enough points and never really look like scoring enough goals. I like how they try and play football but it’s so hard to do that end of the table and in such poor form.
That was such a frustrating game for Tottenham last week against Chelsea. I thought they were brilliant and deserved that two-goal lead but just seemed to collapse and committed daft mistakes. Ange Postecoglou must be so frustrated watching that.
One to watch - This feels like a must-win for Spurs and Ange, Dejan Kulusevski has been a key player for them so far this season. I fancy them to get it, but Southampton could make it nervy.
Brighton 1-1 Crystal Palace
Brighton have obviously made a great start to the season but honestly, it could be so much better. They’ve dropped points from winning positions and if they could have held on to them, they’d probably even be in the title race. They shouldn’t be blowing two-goal leads to Leicester.
Crystal Palace have turned a corner in recent weeks, I thought they were excellent against Manchester City and on another day, they win that game. They’ve made themselves hard to beat but they could do with scoring a few more.
Obviously, there’s a bit of a needle here and it is a derby for the two sides. I can see Palace going down and frustrating Brighton.
One to watch - I don’t often pick a centre-back here, but Maxence Lacroix has been excellent of late. He got a goal for Palace last week and will need to be at his best against such a dangerous Brighton attack.
Nottingham Forest 1-1 Aston Villa
Nottingham Forest are playing so well right now, they were superb against Manchester United last week. They’ve got a nice balance in the side, solid at the back with some real quality on the break.
It’s been an important week for Aston Villa. They got a narrow win over Southampton and that dramatic win against RB Leipzig in the week, they needed that.
I really can’t split these two in current form. I’ve been so impressed by Forest; I think they’ll get a point at home.
One to watch - I think Morgan Gibbs-White is a joy to watch when he’s at his form. He got a goal at Old Trafford and is usually involved in everything Forest do.
Newcastle 2-1 Leicester
Talk about a big game for Newcastle and Eddie Howe. It seems like they’ve lost a bit of momentum, and they really need a win here. Howe’s done such a terrific job here but as we all know, there’s not much loyalty in the game these days.
It’s been a great start for Ruud van Nistelrooy, what point that was against Brighton. The main man Jamie Vardy was right at the heart of it, he shows no sign of slowing down!
Surely Newcastle get the win here, 2-1.
One to watch - Leicester’s defence isn’t the strongest, and Newcastle are likely to create chances. If any fall to Alexander Isak, I’d back him to capitalise.
Bournemouth 2-1 West Ham
Two of my old sides here, this should be a good one! Things just keep getting better for Bournemouth, three wins in a row! That was certainly dramatic at Ipswich, but Andoni Iraola made some changes, and he got his reward late in the game. Three points here and who knows, they could even start dreaming of a top six finish!
That was a massive win for Julen Lopetegui on Monday night, but I don’t think it will ease the pressure too much, particularly with the form they’ve shown on the road. It was nice to see the tributes to Michail Antonio, all that matters is that he is on the mend, all the best to him.
Bournemouth could go nine points clear of West Ham here, that would be amazing for them. I fancy them to get it, 2-1.
One to watch - Bournemouth are full of players that go under the radar, Evanilson is one of them. He was brought in for huge money to replace Dominic Solanke, but he’s been doing a great job in recent weeks and is such a handful up top.
Wolves 2-1 Ipswich
This is a massive game for Gary O’Neil. Again, I feel like I’ve said this so many times, but they really weren’t that bad in the defeat at West Ham. They had a few chances and a few decisions that didn’t really go their way.
Ipswich keep repeating the same mistakes. They’ve lost so many points from good positions this season and I don’t really understand why. It’s got to be a worry for Kieran McKenna, it’s bound be psychological at this point.
I just think Wolves should have too much quality here.
One to watch - In terms of ability, Matheus Cunha should be comfortably the best player on the pitch here. He needs to show it though.