The Reds begin their campaign away at newly promoted Ipswich Town, giving the Dutchman his first taste of Premier League football as Liverpool boss.
Ahead of his debut as manager, former Liverpool striker Michael Owen was asked by AceOdds what will be the main challenges for Slot as he tries to fill the huge shoes left behind by Klopp - and Owen believes there's a lot to do.
"Well, everything really," he said.
"Expectation. You come into a club where there's no room for error really, winning the league or winning the Champions League or finishing second and winning a couple of cups or whatever it might be. I mean, there's not much room for error.
"Demands are high, expectations high, coming off the back of a great decade of football, not just football that's turned into trophies, but real amazing nights, amazing games, great style of play.
"I think the whole package really. You don't come to Liverpool and get an easy ride. In terms of now, the pressure's off. I mean, it ramps up another 10 levels probably. So, he's got loads of struggles, twists, turns, challenges and everything else everywhere he turns really. That's what comes with the title.
Live on DAZN: Juan Francisco Estrada vs. Jesse "Bam" Rodriguez on June 29. Click here for details .