The Bills come into Week 13 fresh off a bye week and looking to strengthen their lead at the top of the AFC East.
They welcome a 49ers team off the back of six straight wins and aim to make it seven at the Highmark Stadium.
It's not so rosy for San Francisco who were comfortably beaten 38-10 by the Green Bay Packers to make it back-to-back defeats.
Here's everything you need to know about Buffalo Bills vs. San Francisco 49ers.
Buffalo Bills vs. San Francisco 49ers date, start time
It's Sunday Night Football from the Big Apple, where US fans can watch the Bills take on the 49ers at 8:20 pm ET/ 7:20 pm central. It's a late one for fans in the UK, with kick-off coming at 1:20 am for those wanting to catch the action.
Its top of the AFC East against the bottom side of the NFC West in a must-see Monday night clash.
- Date: Sunday, December 1
- Kick-off: 8:20 pm / 1:20 am GMT
Thanksgiving / Black Friday NFL Offer
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Being Thanksgiving, all 32 franchises are in action this week, so it is set to be one of the most compelling of the entire regular season, as the race of the playoffs heats up.
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Where is Buffalo Bills vs. San Francisco 49ers?
The game takes place at the Highmark Stadium in Orchard Park, New York City.
Since the 1970s, the stadium has had several different name changes, opening as Rich Stadium before being branded as Highmark in 2021.
How to watch Buffalo Bills vs. San Francisco 49ers on DAZN
Every NFL game during the 2024 regular season and playoffs — including the Super Bowl — is available worldwide on DAZN, excluding the United States and China.
DAZN is the only place to watch NFL Game Pass International, with access to every regular-season NFL game and every playoff matchup. That's 335 games per season, and each game is available live* and on demand.
NFL GPI will be available through the DAZN app either as a standalone subscription or an add-on to an existing DAZN package to customers worldwide**, excluding the United States and China.
* In the United Kingdom, up to two Sunday games per week will air on DAZN on a 24-hour tape delay.
** Viewers in Canada can access all NFL content through their regular DAZN subscription.
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